What is Bethesda?
Sometimes doctors assign names such as "Bethesda Unit" to certain measures of biological activity. In this case, the Bethesda units are measurement of how effective the antibody is inhibiting the blood clotting factor. People who have a health -called haemophilia that come from the inability to clot blood properly require medical care to help control bleeding. Some people with this disease develop antibodies that block circulating blood coagulation factors and worsen the symptoms of the disease. One unit of Bethesda is a measure of how much the patient's antibody can block half the blood factory activity in half an hour at 37 ° Celsius.
Blood clotting is a group of molecules that healthy people do and circulating around in the bloodstream. When a person suffers a cut or begins to bleed, internally or externally, then the factors of blood clotting cooperate to signal the body to correct the point where the blood passes to stop the bleeding. People who have haemophilia have a geneticProblems in creating a healthy level of blood factors and therefore have problems such as uncontrolled bleeding.
Modern medicine can treat these patients by synthetic forms of blood coagulation factors and other drugs that normally help the blood clot. In addition, people with haemophilia may have a certain level of blood coagulation factors that naturally move around the body. However, some people on the condition may develop antibodies against factors that can make haemophilia more dangerous even when treated. The antibody is a molecule that the immune system creates and which can recognize specific substances. Once he recognizes the substance, he tells the immune system to try to destroy or remove it otherwise.
The reason why the body develops these antibodies of clotting factors, thereby reducing the ability of a haemophile patient to stop bleeding after injury. It is important that the physician knows whether the patient developed protrumIlátátka. It must also know how strong the effect of antibodies on blocking the clotting factors is.
Measurement can help doctors find out which drugs can help improve the symptoms of the patient. All measurements require standard units and the Bethesda unit is a unit for measurement. The Bethesda unit is defined as the amount of antibody that can block half of the activity colliding factor for two hours at 37 ° C.
typically is measured by mixing the plasma component of blood from the patient and plasma from a healthy person in the ratio of 50:50. After two hours are higher, the blood clotting levels in the sample are compared with a control pattern that contains only healthy plasma, and therefore the normal level of clotting factor is no antibodies. The result is then converted to Bethesda units by placing in a graph that contains known comparative values.