How effective is Natalizumab for multiple sclerosis?

Many medical studies were performed to evaluate the use of Natalizumab for multiple sclerosis (MS). Most of these studies have concluded that Natalizumab is usually effective in reducing the speed of relapse and morbidity at rapidly developing serious relapsed multiple sclerosis. Despite their effectiveness, the potential risks of Natalizumab may be serious and include allergic reactions, fatigue and slightly increased incidence of progressive multifocal leuoencephalopathy.

Sclerosis is a progressive neurological disorder in which myelin that surrounds the nerve cells in the brain and spinal cord is damaged by the patient's immune system. This disease is characterized by several areas of inflammation or lesions - which are clearly visible to the brain and mixes they imagine. There are several types of multiple sclerosis and the symptoms differ very much between patients. MS can develop throughout their lives. Women are slightly mood prone than men.

some components of the immune systemThey are usually broken in multiple sclerosis. Integrins are a family of immune system molecules. They are important in determining whether inflammatory cells can exceed the blood barrier and enter the brain. When they are defective, integrins allow excess inflammatory cells through the blood -brain barrier, leading to inflammation and relapse in patients with MS. Natalizumab is a monoclonal antibody that blocks the effects of integrine alpha 4, which reduces the frequency of exacerbations and the formation of new lesions of the brain and spinal cord.

It uses intravenous infusion for the administration of natalizumab. The typical dose of Natalizumab for multiple sclerosis is 300 milligrams every 28 days. The drug acts as immunosuppressants, so the possible side effects include an increased risk of opportunistic infections and slightly higher ineustal progressive multifocal leuoncephalopathy. Patients undergoing Natalizumab treatment should not use other immunosupersSive drugs such as interferon beta, immunoglobulins or cyclophosphamide due to potential drug interactions.

There are many types of multiple sclerosis and the disorder can have different degrees of severity. Natalizumab is usually used as a separate therapy for rapidly developing severe relapse-ruffling multiple sclerosis, a MS form, which includes at least two serious relapses per year and the presence of more lesions in imaging studies. The use of Natalizumab sometimes includes other types of multiple sclerosis in patients suffering from frequent, serious exacerbations that cannot be controlled by other medicines and Crohn's disease. Scientific studies on the effects of natalizumab on multiple sclerosis suggest that the drug is more effective than other treatment or lack of treatment in reducing the degree of relapse of patients who have a serious disease.