What are the effects of clomifen in men?
The effects of clomifen in men are increased testosterone production and therefore increased sperm production. The drug works by disrupting the system that usually says pituitary gland to stop producing testosterone. This system includes pituitary gland in the brain and Leydig's cells in the testes. Studies have shown that the use of clomifhen in men is not as effective as in women - but this is in line with data that shows that couples are less likely to become pregnant if a man must use fertility drugs rather than a woman. Clomiphene is not approved by the United States Administration Food and Drug Administration (FDA) for use in men.
Understanding the effects of clomifhen in men requires general knowledge of the testosterone production process. The pituitary gland releases a hormone called luteinizing hormone (LH), which is transported to Leydig cells in the testes and serves as a chemical messenger. Leydig's cells receive LH and start to produce testosterone, draws it into the body. Testosterone relaxed into the body is converted into estrogen that isreturns to the pituitary. The pituitary gland takes an excess of estrogen as a signal to reduce LH performance and thus testosterone.
The use of clomifen in men disrupts this process. The drug prevents estrogen from achieving pituitary gland, causing pituitary gland that there is not enough testosterone in the body. The pituitary sends more LH down to Leydig cells in the testes that react by creating even more testosterone.
The by -product of this hormonal process has led to the use of clomifen to increase the number of sperm in men and improve sperm quality. This may result in a surplus of testosterone produced by Leydig cells. Extra testosterone repairs hormone levels, which can lead to Healthier sperm.
Despite the positive results of tests in the effects of clomifhen in men, the drug is still not approved by FDA for use in men. This is because the company that originally applied for approval has done so by SpeeCally for drug use in women. Research has shown that couples where a man needs fertility treatment will only become 20 to 25 percent of the time compared to 20 to 60 percent when a woman uses treatment.