What is the connection between proteins with and C?
Protein S and C are both molecules that have biological functions in the body. In a situation where a wound is present, for example, the blood flow is to be stopped, the body requires both proteins S and C to help control the range of clotting. Protein C needs proteins S to combine to play their role in the clotting process. When people have a shortage in one or both proteins, they have an increased risk of blood clots.
The blood coagulation process is complex and includes more than 20 different proteins. Each of these proteins interacts with a different one and forms only part of the cascade. The term cascade concerns a biological situation where one molecule affects another, then this interaction causes another substance to change and further in a waterfall effect where the primary molecule determines many other reactions to achieve a specific biological goal. In the case of blood clots, this cascade ends with a cluster of the blood cell plug for the wound.
Every cascade needs certain molecules to control the reaction and achieve the desired final result. However, if the cascade had no regulation, the end result, such as blood clots, would be unusually strong and dangerous to health. Therefore, each cascade is checked at different points by other biological substances, so the clot is properly size and the precipitation stops when the work is completed. S and C proteins are regulatory substances that perform this role.
Bloomed blood flow is protein C as an inactive molecule. Proteins also move in the blood and are uninteresting in an inactive protein C. Only when protein C is activated can it be combined with proteins.
Protein C activation occurs when the levels of the substance known as the active form of thrombomodulin rise and act on protein C. The concentration of activated thrombulin only increases when blood clotting takes place. This is because thrombomodulin is part of a cascade of clotting and jE with another substance called thrombin.
fragments of cells known as plates form the basic cellular structure of the clot. These plates are places where proteins and C bind together. Protein C needs proteins S for binding to perform the necessary regulation.
This complex of two proteins sitting on the surface of the plate is even more proteins in the cascade. The VA factor and the VIIIA factor are molecules that are pro-clotting. They activate another molecule that activates another molecule that turns into thrombin. Here the cascade returns to proteins with and C as a thrombin is a substance that activates thrombomodulin, which in turn activates protein C.
Therefore, the control process may be regulated. Since the level of activated protein C is affected by the level of thrombomodulin, this is indirectly influenced by the levels of all precipitation of the pro-trial molecules. In a healthy person, this constant loop keeps the influence on adequate and useful levels and prevents the discovery of blood clots in nechádých areas. When a person suffers from a deficiency of protein C or protein, this regulation is disturbed and dangerous blood clots may form in the orbital system.