What is flush niacin?
The flush of niacin refers to redness and heat that appears on the skin of the face and the upper body shortly after you take vitamin niacin. The reaction is the result of niacin binding to receptors on cells near the skin surface. These cells then release compounds that cause the blood vessels to spread below the surface. The dilatation of these blood vessels causes the skin flushing.
NIACIN, also referred to as nicotine acid, is one of the vitamins B and is essential to maintain health. It helps in carbohydrate and fat metabolism. Eating a healthy diet of proteins, fruits and vegetables is generally sufficient to maintain an acceptable level of niacin. Niacin has shown to reduce blood cholesterol. Cardiac patients who are threatened by a heart attack due to elevated cholesterol levels may benefit from using niacin supplements.
Diet replenishment of 1,000 to 2,000 mg per day may lead to a decrease in low densototoprotein (LDL) or poor cholesterol, levels and lowering levels of triglyceriSubstantial in the blood. Niacin also increases the levels of high density lipoproteins (HDL), which are used to protect the heart by transmitting bad cholesterol from arteries to the liver. Doctors can prescribe niacin in combination with statin -reducing cholesterol.
Many patients experience side effects after using niacine supplement. Niacin flushing, which can lead to unpleasant redness and heat in the upper body, can last up to one hour after ingestion of niacin. Other side effects may include armor, pain or itching. Many patients stop taking niacin because of these side effects.
Once niacin is accepted, it acts by tying the receptor on the cells under the skin. This receptor is known as a receptor 109A associated with G-Protein (GPR109A). It is present on the surface of cells in the shape of a spindle of Cbuňky Ald Langerhans. After activation, the Langerhans cells begin to release two types of prostaglandin molecules, pgd2 andPGE2.
These prostaglandins are similar to hormones and are derived from lipids. Prostaglandin molecules interact with smooth muscle cells and cause blood vessels dilatation. The dilatation of these vessels on the surface of the skin causes niacin to rinse.
Most patients taking niacin experience niacin over time over time. As Niacin levels stabilize in the blood, patients develop tolerance to niacin and rinse should be reduced. Niacin formulation with slow release can also help reduce niacin rinse. Aspirin or non -steroidal anti -inflammatory drugs (NSAIDs) may reduce flushing by breaking the production of prostaglandins by Langerhans cells. Removal of unpleasant repayment can be niacin more attractive as therapy for cardiac patients.