What is toxin pertussis?

pertussis toxin is a large protein produced bordatella pertussis, causal reagent cough. Toxin is also known as PT, toxin is a large protein composed of six subunits. It is exotoxin and is released from bacterial cells in inactive form. After being taken into cells, it is activated and disrupted by intracellular signaling mechanisms of its host cells and facilitates the bacterial colonization of the infected person. This bacterial disease is one of the contagious diseases that affects both children and adults, despite the existence of a vaccine against the body. In each PT molecule there are two S4 subunits. This type of toxin is known as toxin A/B. Part of the toxin pertussis consists of S1, has enzymatic activity and can catalyze chemical reactions. Once a suitable compound is reminiscent of it, it triggers cellular activity. Binding B Parts B Pertussis toxin causes activation of subunit A. Once this subunit is active, it disrupts the host's immune response.

An important part of the human immune system is activation of receptors called G proteins. They stimulate many paths involved in immunity. If their activity is blocked, it can significantly disrupt the ability to bounce a pathogenic attack. Activation of the Pertussis toxin toxin and allows you to add adp-ribosis to one form of G protein, significantly braking intracellular signaling and interferes with the immune response to the infection of this bordatella pathogen.

The

toxin subunit Pertussis S2 and S3 bind to receptors on different cell types. Subedus 3 can bind to the surface of cells called phagocytes whose function is taken and absorbed by bacteria and other attackers. It is not clear why the pathogen will start this answer. One hypothesis is that by being inside these specialized cells, pathogenic bacteria are able to reduce another aspect of the immune system. Normally you wouldo Cells produced toxic oxidized products that would kill bacteria in the vicinity.

Biochemical research G proteins often uses toxin pertussis, which is commercially available. The ability of this subunit to add adp-ribosis to G protein causes its activity to be separated from any reaction of the receptor G protein. This is useful for G protein studies. It is available in inactive form and does not require activation when used with cellular extracts or cells, but when experiments include purified G protein.