What is seronegative rheumatoid arthritis?
autoimmune disease, seronegative rheumatoid arthritis, can produce the same symptoms as rheumatoid arthritis (RA), although blood samples usually do not show rheumatoid factor (RF) commonly associated with disorder. Up to 20 percent of patients suffering from this chronic inflammatory disease initially do not show RF, although some eventually transform themselves into seroposive, causing a factor with the disease progress. In advanced cases, there are usually inflammation, pain and damage to the joints and other body systems may also be involved. Healthcare providers generally treat seronegative rheumatoid arthritis based on symptoms and disease progression.
Seronegative rheumatoid arthritis begins with cellular and humoral immune responses in the body. White blood cells from bone marrow and thymus begin to create antibodies. These white blood cells and chemicals that produce are attacked by body tissue, especially joints. The first seronegative rheumatoids of arthritis usually occurThe dilution of joints and generally involves depression, fatigue and malaise, which can be accompanied by a low degree fever. After two or three months, patients experience inflammation, pain and sensitivity in one joint.
As the disease progresses, more joints of the limbs are involved. Morning rigidity and joint pain continue for hours, which is a symptom that usually differentiates RA from other types of arthritis. Seronegative rheumatoid arthritis usually produces swelling and tenderness of the joints along with heat and pain during movement. These symptoms occur because the autoimmune response causes inflammation of the tendon, which can lead to the formation of cyst and possible rupture of connective tissue. Loss of connective tissue usually causes the erosion and proliferation of bone cells, leading to joint deformities.
Totok and inflammation commonly associated with seronegative rheumatoid arthritis can also compress sensitive nerve tissue, causing BOlest nerve. Patients may also experience symptoms related to muscle involvement. Autoimmune response can proceed and eventually include cardiac and pulmonary systems, causing inflammation, fluid accumulation and tissue fibrosis. Some develop a condition known as Sjogren's syndrome in which white blood cells infiltrate selves, salivary and exocrine glands that inhibit normal body fluid flow.
Definitive diagnosis of seronegative rheumatoid arthritis often represents a challenge in early stages. Not only do patients do not show RF in blood samples, symptoms may come and leave. Individuals could experience exacerbation of symptoms for 24 to 48 hours followed by complete resolution. Some people have a complete remission within six months of the beginning of the initial symptoms. The development of anti-cyclic citrullinatacre tests of ED protein antibodies (Anti-CCPP) helped identify the disease in some patients who usually do not produce RF.
healthcare providers generally prescribeThey take drugs for seronegative rheumatoid arthritis that correlate with symptoms. Non -steroidal anti -inflammatory and corticosteroid drugs generally help reduce inflammation and swelling. If X-rays indicate the joint narrowing, doctors may administer anti-rheumatoid drugs modifying the disease, also referred to as DMARD to reduce the risk of joint damage and deformity.