What is Nesidioblastosis?

Nesidioblastosis is a dangerous persistent hypoglycaemia or low blood glucose, which is caused by too much insulin, a condition called hyperinsulinism if it is not caused by a tumor producing insulin. Hypoglycaemia is a potentially dangerous condition that can cause symptoms such as headache, confusion, vibration, blurred vision and heart palpitations. It can also cause seizures, brain damage, coma or even death. Infants with this condition need surgery to remove part of the pancreas - called partial pancreaticia - or may suffer serious brain damage or death.

Scientist George F. Laidlaw created the term "non -sidioblastosis" in 1938 to refer to infants with abdominal pancreatic abnormalities, including too many pancreatic beta cells, beta cells where they should not be and greater than normal beta cells. The term "non -sidioblastosis" fell out of kindness when scientists found that some people have physical features of non -Nesidioblastosis without beingThey developed hypoglycaemia, so doctors began to identify disorders instead of their symptoms, such as persistent hyperinzulinemic hypoglycaemia of childhood (phhi) or congenital hyperinsulinism. Scientists at the age of 80 have found that many patients with hyperinsulinism have lower somatostatin levels, a hormone that inhibits insulin release, so hyperinsulinism involves more than just an abnormal beta cell. Although the persistent hypoglycaemia caused by hyperinsulinism usually occurs in children aged 2 or younger, when the pancreas is still evolving, physics began to use the term "non -ovioblastosis" in the early days of surgery on lining.

At the age of 30, doctors noticed that some children who had developed serious persistent hypoglycemia had a very high level of insulin in their blood. Pathologs found that many of these children had specific pancreatic abnormalities involving beta cells,which are cells producing insulin located in Langerhans pancreatic islands. Children with severe hypoglycaemia have increased beta cells and beta cells where there should be none, for example in and around pancreatic channels.

scientists in the 70s and 80s have found that some people have pancreatic abnormalities observed in non -uglastosis without experiencing persistent hypoglycaemia or hyperinsulinemia. Pathologists found abnormal production and placement of beta cells in people with cystic fibrosis, Zollinger-Ellison syndrome or sudden infant death and even in healthy infants. Hyperinsulinism is usually not caused by the problems with beta cells, but a combination of problems, including too little delta of pancreatic cells that release somatostatin, a hormone that inhibits insulin release. These discoveries have caused the name "non -Nesidioblastosis" falls out of kindness in many doctors, so "preferred terms have become" congenital hyperinsulinism "Splasia "and" cell dysmaturation syndrome ".

Although non -sidioblastosis almost always occurs in children aged 2 or younger, rare cases may occur in adults, sometimes as a side effect of the stomach of the stomach. At the beginning of 2011, the cause of Nesidioblastosis remained unclear. Some adults with non -Nesidioblastosis have antibodies against beta cells in their blood serum, which could cause beta cells to grow too much in response to attacking the body's immune system; Other adult patients with non -Nesidioblastosis have high levels of some factors of beta cell growth and a higher number of receptors for the growth of beta cells in the pancreatic, which could cause abnormally beta cell growth. Both of these conditions were found in patients with stomach bypass who develop non -life. Nesidioblastosis is a rare complication of stomach bypass, a serious nature of the disorder and the increasing number of stomach procedures mean that doctors need postoperative patients aboutHypoglycaemia and hypoglycaemic patients for non -sidioblastosis.