What is peptidomimetics?

Peptidomimetics is a compound that is designed to mimic biologically active peptide, but has structural differences that provide greater advantages for its function as a medicine. For example, peptidomimetics, which is designed to imitate hormones, would have more stability and would be more available to the target signal transmission receptor. Peptide is a large molecule made of amino acids that are associated with peptide bonds. Peptidomimetics may have unnatural amino acids or other unusual compounds to stabilize their structure or change their biological activity. This means that they can act as hormones and signal molecules for the central nervous system and the immune system. Peptides can affect a wide range of cellular activity, including digestion, reproduction and sensitivity to pain. Many peptide activities are interesting as drug goals, but it may be difficult for them to exceed Masto to enter the cell. Also the peptides that make it into the cells are often nestaa billet.

Peptidomimetics were first designed to reduce the conformation mobility of the peptide - in other words to what extent it can bend. After determination of peptides on site, it increases the likelihood of reacting with their desired goal and limiting adverse side effects. Another goal is to increase their stability. Incorporating unnatural compounds into their spine makes it much less likely that these new compounds will be degraded by enzymes that break down peptides and peptidomimetics.

peptides consist of amino acid chains connected by peptide bond between carboxes at the end of one amino acid and amino the end of another. There are many ways to change peptidomimetics. Peptidomimetics may have a peptide bond completely relocated, replaced by beta amino acids that contain two other carbon atoms between amino and carboxes terminus of two adjacent amino acids. It canlead to a wide range of configurations that are biologically active and resistant to collapse.

Organic chemists have identified many other ways to replace peptide bond. In addition, side chains often change, sometimes by adding cyclic peptides. These are peptides in which amino -Kon and carboxes are connected by the end of the same molecule. All these changes are usually designed to increase peptidomimetics stability.

6 Transport across biological membranes is another factor that can be improved by targeted synthesis of peptidomimetics. Detailed knowledge of the goal is required to make these decisions.

This approach was very valuable for identifying new active compounds. Using this method has developed some successful drugs, including the peptidomimetic inhibitor of the enzyme converting angiotensin (ACE), which is used to treat high blood pressure and other conditions. Other peptidomimetic inhibitors include those that are designed to triggerCancer cells to get into programmed cell death, known as apoptosis . Several research laboratories have been successful with this technique in model systems and at least one patent was used in this area.

Peptidomimetic synthesis may be under the structure for a particular compound or large libraries can be synthesized and checked. An example of the last approach uses combinatoric chemistry. This is the strategy of synthesizing a large number of molecules that are structurally related. The library of produced compounds can then be proven for active compounds.

Peptidomimuetic field design exceeds a number of scientific disciplines. The rate of success for identifying biologically active compounds from peptidomimetic compound libraries is much higher than from screening libraries of peptides. With frequent advantages of increased stability and availability for their objective, the field of peptidomimetics increases.